2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  4. Casein Kinase

Casein Kinase

Casein Kinase

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Casein Kinases (CKs), a group of ubiquitous Ser/Thr kinases, regulate a wide range of cellular functions in eukaryotes, including phosphorylation of proteins that are substrates for degradation via the ubiquitin-proteasome system (UPS). Two casein kinases, casein kinase-1 (CK-1) and casein kinase-2 (CK-2), have been characterized from many sources.

CK1 kinases exist in at least seven isoforms (α, β, γ1-3, δ, and ɛ) in mammals and CK1 kinases phosphorylate various substrates to play vital roles in diverse physiological processes such as DNA repair, cell cycle progression, cytokinesis, differentiation, and apoptosis. Casein kinase 2 (CK2) is a highly pleiotropic serine-threonine kinase, which catalyzed phosphorylation of more than 300 proteins that are implicated in regulation of many cellular functions, such as signal transduction, transcriptional control, apoptosis, and the cell cycle.

Casein Kinase Isoform Specific Products:

Casein Kinase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155958
    Casein kinase 1δ-IN-9
    		Inhibitor ≥98.0%
    Casein kinase 1δ-IN-9 (compound 737) is a potent casein kinase 1δ (CK1δ/CK15) inhibitor. Casein kinase 1δ-IN-9 can be used for the research of neurodegenerative disorders such as Alzheimer's disease.
    Casein kinase 1δ-IN-9
  • HY-117332
    IQA
    		Inhibitor
    IQA (CGP-029482) is a potent and selective protein kinase CK2 inhibitor.
    IQA
  • HY-P3748
    Casein Kinase II Receptor Peptide
    		Chemical
    Casein Kinase II Receptor Peptide is a substrate for casein kinase II with an Km value of 500 µM. Casein Kinase II Substrate can be used for measure casein kinase II activity in crude enzyme preparations.
    Casein Kinase II Receptor Peptide
  • HY-W011109
    CKI-7
    		Inhibitor
    CKI-7 is a potent and ATP-competitive casein kinase 1 (CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1 (S6K1) and mitogen- and stress-activated protein kinase-1 (MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases.
    CKI-7
  • HY-169692
    Casein kinase 1δ-IN-21
    		Inhibitor
    Casein kinase 1δ-IN-21 (compound 501) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-21 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-21
  • HY-171277
    Casein kinase 1δ-IN-27
    		Inhibitor
    Casein kinase 1δ-IN-27 (Compound 8) is the inhibitor for casein kinase 1 that inhibits CK1α, CK1δ, CK1ε, and p38α with IC50s of 22, 16.5, 9.41 and 14.8 nM, respectively. Casein kinase 1δ-IN-27 inhibits the DUX4 expression with an IC50 of 10 nM.
    Casein kinase 1δ-IN-27
  • HY-169347
    dCK1α-2
    		Degrader
    dCK1α-2 is an orally active CK1α molecular glue degrader that targets p53 pathway-related targets. dCK1α-2 exhibits anti-tumor efficacy in mouse models and can increase the expression of p53-related genes..
    dCK1α-2
  • HY-170859
    AH078
    		Inhibitor
    AH078 (compound 37) is a PROTAC degrader that selectively targets CK1δ and CK1ε, and has low targeting for CK1α. AH078 consists of PROTAC linker (black part) Monomethyl octanoate (HY-W001958), target protein ligand (red part) (HY-170860) CK1δ/CK1ε liagnd-1 and E3 ligase ligand (blue part) E3 ligase Ligand 58 (HY-170861). Among them, E3 ligase ligand + linker can form a conjugate E3 Ligase Ligand-linker Conjugate 163 (HY-170862).
    AH078
  • HY-169709
    Casein kinase 1δ-IN-26
    		Inhibitor
    Casein kinase 1δ-IN-26 (compound 505) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-26 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-26
  • HY-156913
    Casein kinase 1δ-IN-13
    		Inhibitor
    Casein kinase 1δ-IN-13 (compound 401) is a Casein kinase 1δ inhibitor. Casein kinase 1δ-IN-13 can be used in neurodegenerative disease research.
    Casein kinase 1δ-IN-13
  • HY-151382
    CK2-IN-3
    		Inhibitor
    CK2-IN-3 is a selective and potent CK2 inhibitor (Kd: 12 nM), with IC50 values of 1.51 μM (CK2α) and 7.64 μM (CK2α’). CK2-IN-3 can be used in the research of cancers.
    CK2-IN-3
  • HY-B0183A
    Ellagic acid (hydrate)
    		Inhibitor
    Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM.
    Ellagic acid (hydrate)
  • HY-155987
    CK2-IN-8
    		Inhibitor
    CK2-IN-8 (compound 5c) is a CK2 inhibitor with IC50 >33 μM.
    CK2-IN-8
  • HY-158369
    CK2-IN-10
    CK2-IN-10 (31), an allosteric CK2 inhibitor, can be used in the research of cancer.
    CK2-IN-10
  • HY-171279
    Casein kinase 1δ-IN-29
    		Inhibitor
    Casein kinase 1δ-IN-29 (Compound 18) is the inhibitor for p38α and casein kinase 1 that inhibits p38α, CK1δ and CK1ε with IC50 of 0.041 µM, 0.005 µM and 0.447 µM, respectively. Casein kinase 1δ-IN-29 arrests cell cycle at subG1 phase, induces apoptosis in cell AC1-M88.
    Casein kinase 1δ-IN-29
  • HY-169702
    Casein kinase 1δ-IN-23
    		Inhibitor
    Casein kinase 1δ-IN-23 (compound 423) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-22 can be used in the study of neurodegenerative diseases such as Alzheimer's disease.
    Casein kinase 1δ-IN-23
  • HY-12570
    CK2-IN-9
    		Inhibitor
    CK2-IN-9 is a potent and selective inhibitor of CK2 kinase with an IC50 of 3 nM. CK2-IN-9 reduces Wnt reporter activity with an IC50 of 75 nM. CK2-IN-9 has low exposure (AUC=0.36 μM/h) and high clearance (CL=65 mL/min/kg) properties in rat.
    CK2-IN-9
  • HY-162078
    Antiproliferative agent-46
    		Inhibitor
    Antiproliferative agent-46 (compound 5e) is an inhibitor of the casein kinase-2 enzyme (CK2) receptor. Antiproliferative agent-46 has a potent antiproliferative activity with an IC50 value of 5.75 μM on the U87 cell line.
    Antiproliferative agent-46
  • HY-153747
    Casein kinase 1δ-IN-4
    		Inhibitor ≥98.0%
    Casein kinase 1δ-IN-4 (compound 567) is a potent casein kinase 1δ inhibitor. Casein kinase 1δ-IN-4 has the potential for the research of Alzheimer's disease.
    Casein kinase 1δ-IN-4
  • HY-149292
    SR-4133
    		Inhibitor
    SR-4133 is a potent and highly CK1ε selective inhibitor with an IC50 of 58 nM. SR-4133 binds to the ATP-binding site of CK1ε. SR-4133 displays nanomolar growth inhibition of bladder cancer cells, and inhibits the phosphorylation of 4E-BP1.
    SR-4133
Cat. No. Product Name / Synonyms Application Reactivity
Casein Kinase Isoform Comparison

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